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Publications

  1. Ratmir Derda, Samira Musah, Brendan P. Orner, Joseph R. Klim, Lingyin Li, and Laura L. Kiessling*
    "High-Throughput Discovery of Synthetic Surfaces That Support Proliferation of Pluripotent Cells" J. Am. Chem. Soc. 2010, In press.


  2. Yu Zhang, Siti Raudah Mohamed Lazim, Huihian Teo, Gwenda W. S. Teo, Rongli Fan, Xiaoming Sun, Brendan P. Orner* “Alanine Shaving Mutagenesis to Discover Key Residues in the Folding and Self-Assembly of a Mini- and a Maxi-Nanocage Protein”, Journal of Biological Chemistry 2010, accepted.


  3. Rongli Fan, Aimee L. Boyle, Vee Vee Cheong, See Liang Ng, Brendan P. Orner* “A Domain Swapping Study of Two Protein Cages”, Biochemistry 2009, 48, 5623-5630.


  4. Limin Yu, Peggy Shuang, Elizabeth Yee Yen Mui, Jennifer C. McKelvie, Thi Phuong Tu Phama, Yan Wen Yap, Wan Qing Wong, Jiawen Wu, Weiqiao Deng, Brendan P. Orner* “Phage display screening against a set of targets to establish peptide-based sugar mimetics and molecular docking to predict binding site”, Bioorganic & Medicinal Chemistry 2009, 17, 4825–4832


  5. Yueqin Fang, Wan Qing Wong, Yan Wen Yap, Brendan P. Orner* “Stem Cells and Combinatorial Science”, Combinatorial Chemistry & High Throughput Screening 2007, 10, 635.
     

  6. Ratmir Derda, Lingyin Li, Brendan P. Orner, Rachel L. Lewis, James A. Thomson, Laura L. Kiessling, "Defined Substrates for Human Embryonic Stem Cell Growth Identified from Surface Arrays", ACS Chemical Biology, 2007, 2, 347.
     

  7. Yueqin Fang, Brendan P. Orner*, “Induction of Pluripotency in Fibroblasts Through the Expression of Only Four Nuclear Proteins”, ACS Chemical Biology, 2006, 1, 557-558.
     

  8. Brendan P. Orner, Lin Liu, Regina M. Murphy, Laura L. Kiessling, "Phage Display Affords Peptides that Modulate β-Amyloid Aggregation", J. Am. Chem. Soc. 2006, 128, 11881-11889.
     

  9. Hang Yin, Gui-in Lee, Kristine A. Sedey, Olaf Kutzki, Hyung Soon Park, Brendan P. Orner, Justin T. Ernst, Hong- Gang Wang, Said M. Sebti, Andrew D. Hamilton, "Terphenyl-Based Bak BH3 α-Helical Proteomimetics as Low- Molecular Weight Antagonists of Bcl-xL", J. Am. Chem. Soc. 2005, 127, 10191-10196. (note: This paper is attributed to “Brendan P. Omer” in web of science)
     

  10. Brendan P. Orner, Ratmir Derda, Rachel L. Lewis, James A. Thomson, Laura L. Kiessling, "Arrays for the Combinatorial Exploration of Cell Adhesion", J. Am. Chem. Soc. 2004, 126, 10808-10809.
     

  11. Olaf Kutzki, Hung-Sun Park, Justin T. Ernst, Brendan P. Orner, Hang Yin, Andrew D. Hamilton, "Development of a Potent Bcl-xL Antagonist Based on α-Helix Mimicry", J. Am. Chem. Soc. 2002, 124, 11838-11839.
     

  12. Brendan P. Orner, Xavier Salvatella, Javier de Mandoza, Ernest Giralt, Andrew D. Hamilton, "De Novo Protein Surface Design: Use of Cation-π Interactions to Enhance Binding Between an a-Helical Peptide and a Cationic Molecule in 50% Aqueous Solution", Angew. Chem., Int. Ed. Engl. 2002, 41, 117-119.
     

  13. Brendan P. Orner, Justin T. Ernst, Andrew D. Hamilton, "Towards Proteomimetics: Terphenyl Derivatives as Structural and Functional Mimics of Extended Regions of an α-Helix", J. Am. Chem. Soc. 2001, 123, 5382-5383.
     

  14. Brendan P. Orner, Andrew D. Hamilton, "The Guanidinium Group in Molecular Recognition: Design and Synthetic Approaches", J. Inclusion Penom. Macrocyc. Chem. 2001, 41, 141-147.
     

  15. Mark W. Peczuh, Brendan P. Orner, Andrew D. Hamilton, "In Recognition of Proteins", Chemistry in Britain 2000, 36, 43-45.
     

  16. Brian Linton, Andrew J. Carr, Brendan P. Orner, Andrew D. Hamilton, "A Versatile One-Pot Synthesis of 1,2- Substituted Guanidines from Carbamoyl Isothiocyanates", J. Org. Chem. 2000, 65, 1566-1568.
     

Patents

 

  1. Laura L. Kiessling, James A. Thomson, Brendan P. Orner, Ratmir Derda, "Combinatorial Approach to Screen for Stem Cell Adhesion and Long-Term Proliferation", U. S. Patent Application: 20070207543 Sept. 6, 2007 (Preliminary U. S. Patent P05364US April 20, 2005).

  2. Andrew D. Hamilton, Justin T. Ernst, Brendan P. Orner, "Proteomimetic Compounds and Methods", U. S. Patent, 20050215563 September 29, 2005 (Prelim patent: 20030008882, May 8, 2002).

 

 

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