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LIU Xuewei

Associate Professor

Education: B.Sc., M.Sc., China Agricultural University; Ph.D., University of Southern California, Post-doc: Caltech

Research Area: New Synthetic Methodology; Natural Product Synthesis; Cell Surface Chemistry; Transmembrane Activities of Molecules

Phone: (65) 6316 8901

E-mail: xuewei@ntu.edu.sg

Webpage: http://www.ntu.edu.sg/home/xuewei/

Research Interest

Glycobiology-Oriented Synthesis

Two major impediments to the rapidly growing field of molecular glycobiology are 1) the lack of pure, structurally defined complex oligosaccharides and glycoconjugates; 2) the lack of the methods for biological studies. Our research is to develop efficient synthetic methods to construct the challenging complex oligosaccharides, functionalize carbon nanotubes with them, and use them as biosensors to detect biomolecular release from living cells.

Medicinal Chemistry, Drug Delivery and Synthesis

We are highly interested in natural products, porphyrins and their application in medicinal chemistry and drug delivery. Such as Militarinone A, a family member of pyridone alkaloids, showed distinct neuritogenic properties in PC12 cells. These compounds are frequently isolated in minute quantities, limiting any kind of systematic study. But general synthesis of Militarinone is rarely reported. To further explore the potential of pyridone alkaloids as neuritogenic molecules and for the purpose of structure-activity studies, we develop efficient sequences to assemble complex structures with high levels of stereo-control built in. New methodologies are being developed, which can be extended to other novel areas. In our lab, a special emphasis is placed on organic synthesis and on the utilization of this expertise in addressing problems of medicinal and biochemical significance.  Energy molecules are also being synthesized.

Selected Publications

  1. Jimei Ma, Yanying Zhao, Simon Ng, Jing Zhang, Jing Zeng, Aung Than, Peng Chen,  Xue-Wei Liu, “Sugar-based Synthesis of Tamiflu and Its Inhibitory Effects on Cell Secretion”, Chemistry, A European Journal. 2009, accepted. (IF = 5.3)

  2. Renliang Yang, Kalyan Kumar Pasunooti, Fupeng Li, Xue-Wei Liu*, and Chuan-Fa Liu*, “Dual Native Chemical Ligation at Lysine”, J. Am. Chem. Soc., DOI: 10.1021/ja905491p, in press, 2009. (IF = 7.9)

  3. Rujee Lorpitthaya, Zhi-Zhong Xie, K. B. Sophy, Jer-Lai Kuo and Xue-Wei Liu, “A Theoretical Investigation on the Rhodium-Catalyzed Intramolecular Aziridination of Glycals”, Chemistry, A European Journal. 2009, accepted.  (IF = 5.3)

  4. Sudibya HG, Ma J, Dong X, Ng S, Li LJ, Xue-Wei Liu*, Chen P, “Interfacing Glycoslyated Carbon Nanotube Network Devices with Living Cells to Detect Dynamic Secretion of Biomolecules”, Angew. Chem. Int. Ed. 2009, 48, 2723 –2726. (IF = 10.0)