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LI Tianhu
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Associate Professor

Education: B. Sc., Jilin University; Ph.D., State University of New York

Research Area: Nucleic acid chemistry

Phone: (65) 6513 7364

E-mail: thli@ntu.edu.sg

Webpage: http://www3.ntu.edu.sg/home/thli/


Research Interest

The focuses of my group are mainly on the following research areas:

[1] Atomic force microscopic studies of binding interactions between circular DNA and topoisomerases.


Zhaoqi Yang, Dawei Li, Shuhui Hiew, Magdeline Taotao Ng, Weixing Yuan, Haibin Su, Fangwei Shao and Tianhu Li, Recognition of forcible curvature in circular DNA by human topoisomerase I, Chem. Commun., 2011, 47, 11309-1131

[2] Atomic force microscopic studies of formation of catenated DNA catalyzed by Cre recombinase.

Zhaoqi Yang, Dawei Li and Tianhu Li, Design and synthesis of catenated rings based on toroidal DNA structures, Chem. Commun., 2011, 47, 11930-11932

[3] Examination of correlation between DNA backbone self-crossing and DNA intrinsic curvature on the basis of AFM.

Li, D.;* Yang, Z.; Zhao G.; Long, Y.; Lv, B.; Li, C.; Hiew, S,; Ng, M. T. T.; Guo, J. J.; Tan H. K,; Zhang, H.; Li T.* Manipulating DNA writhe through varying DNA sequences. Chem. Commun., 2011, 47(26), 7479-7481

[4] Manipulation of formation of negative right handed and left handed positive DNA supercoils with desired writhe number.

Dawei Li, Zhaoqi Yang, Yi Long, Guanjia Zhao, Bei Lv, Shuhui Hiew, Magdeline Tao Tao Ng, Juanjuan Guo, HongKee Tan, Hao Zhang, Weixing Yuan, Haibin Su and Tianhu Li, Precise engineering and visualization of signs and magnitudes of DNA writhe on the basis of PNA invasion. Chem. Comm., 2011, 47, 10695-10697

[5] “General Topological Conservation Law of DNA”:

The original form of “Topological Conservation Law” given by F. B. Fuller in 1970s: Lk -Tw = Wr
The new form of “General Topological Conservation Law of DNA” introduced by our group: Lk -Tw + Nb = Wb + Wn = Wr
(see: Dawei Li, Zhaoqi Yang, Bei Lv, Tianhu Li , Observation of backbone self-crossings of organismal DNAs through atomic force microscopy, Bioorganic & Medicinal Chemistry Letters 22 (2012) 833–836)

 

 


Selected Publications

  1. Hong Kee Tan , Dawei Li , Robert Kenneth Gray , Zhaoqi Yang , Magdeline Tao Tao Ng , Hao Zhang , Joel Ming Rui Tan , Shuhui Hiew , Jasmine Yiqin Lee and Tianhu Li, Interference of intrinsic curvature of DNA by DNA-intercalating agents , Org. Biomol. Chem., 2012, 10, 2227-2230 . 

  2. Zhaoqi Yang, Dawei Li and Tianhu Li, Design and synthesis of catenated rings based on toroidal DNA structures, Chem. Commun., 2011, 47, 11930-11932 .

  3. Dawei Li, Zhaoqi Yang, Yi Long, Guanjia Zhao, Bei Lv, Shuhui Hiew, Magdeline Tao Tao Ng, Juanjuan Guo, HongKee Tan, Hao Zhang, Weixing Yuan, Haibin Su and Tianhu Li, Precise engineering and visualization of signs and magnitudes of DNA writhe on the basis of PNA invasion. Chem. Commun., 2011, 47, 10695-10697 2

  4. Liu, D. S.; Chen, J.; Lee, A. H. F.; Chow, L. M. C.; Chan, A. S. C.; Li, T. H., Small circular oligodeoxynucleotides achieved from self-assembling entities. Angew. Chem. Int. Ed., 2003, 42, (7), 797-799.

  5. Lee, A. H. F.; Chen, J.; Liu, D. S.; Leung, T. Y. C.; Chan, A. S. C.; Li, T. H., Acid-promoted DNA-cleaving activities and total synthesis of varacin C. Journal of the American Chemical Society, 2002, 124, (47), 13972-13973.

  6. Li, T.; Nicolaou, K. C., CHEMICAL SELF-REPLICATION OF PALINDROMIC DUPLEX DNA. Nature, 1994, 369, (6477), 218-221.