Sumod A. Pullarkat
C:\Documents and Settings\sumod\Local Settings\Temporary Internet Files\Content.Word\IP3Q9969.jpg

Senior Lecturer

Education: B.Sc., Univeristy of Calicut; M.Sc., M.Phil., Annamalai University; Ph.D., National University of Singapore

Research Area:Applications of Organometallic Complexes in catalysis, biological applications and in development of functional materials

Phone: (65) 6316 8906

E-mail: sumod@ntu.edu.sg

Webpage:http://www3.ntu.edu.sg/home/sumod/Home.html



Research Interest

Development of Transition Metal based Catalytic Systems:


We are currently investigating the use of Ru, Pd and Ir metallacycles and related systems for their potential as catalysts in various organic synthetic scenarios. We are also actively pursuing the development of catalytic protocols for the asymmetric generation of new chiral phosphines from non chiral substrates, especially those incorporating the ferrocenyl moiety and having planar, axial and central chirality elements and their subsequent application in asymmetric synthesis.


Development of High Oxidation State Metal Complexes as Therapeutic agents:


The activation of transition metal based prodrugs by reduction is a plausible pathway that has been attracting increasing attention because their complexes possess a biologically accessible MIV/MIII/MII redox potential. Various ligands have the potential to stabilize high oxidation states of metals like Ruthenium and Iridium. This makes the development of such complexes interesting for the preparation of bio-reductive pro-drugs which are activated by reduction in the acidic extracellular environment of the hypoxic tumor tissue. We are currently working on drug candidates which not only involve high oxidation state metal centres but also incorporate ligands which when liberated could act as iron chelators.
Our other interests include use of organometallic systems in the synthesis of functional materials and the development of high chiral density structural motifs.


 

Selected Publications

  1. K.Chen and S.A.Pullarkat*, A Tandem Heck- aza-Michael Addition Protocol for the One-Pot Synthesis of Isoindolines from Unprotected Amines, Org. Biomol. Chem., 2012, 10, 6600-6606.

  2. C.Xu, V.Kumar and S.A.Pullarkat*, Domino Cyclization-Alkylation Protocol for the Synthesis of 2,3-functionalized Indoles from 0-alkynylanilines and Allylic Alcohols, Org. Biomol. Chem., 2012, 10, 3875-3881. .

  3. C.K.Chen, Y.Li, S.A.Pullarkat* and P.H.Leung*, Palladacycle Catalyzed Tandem Allylic Amination/Allylation Protocol for the One-Pot Synthesis of 2-Allylailines from Allylic Alcohols, Adv. Synth. Catal., 2012, 354, 83-87. .

  4. C.Xu, L.W.Chuan, Y.Li and S.A. Pullarkat*, Ruthenacycles as efficient catalysts for the beta-alkylation of secondary alcohols with primary alcohols, Tet. Lett., 2012, 53, 1450-1455. .

  5. C.Xu, Y.Li, L.Y.Goh and S.A.Pullarkat*, An Ir-thioether-dithiolate Catalyst for low catalyst loading Beta-alkylation and selective imine formation via N-Alkylations Reactions, Organometallics, 2011, 30, 6499-6502.

  6. Y.Huang, R.J.Chew, Y.Li, S.A.Pullarkat* and P.H.Leung*, Direct Synthesis of Chiral Tertiary Diphosphines via Pd(II) catalyzed asymmetric hydrophosphination, Org. Lett., 2011, 13, 5862-5865.