Hello! We have migrated to a new site - Click here to view our latest information.
LEUNG, Pak-Hing
leung ph

Professor
Associate Chair (External Relations)

Education: B.Sc. (Hon.), Polytechnic of North London; Ph.D., Australian National University, Post-doc: Toronto, Chicago

Research Area: Asymmetric synthesis; Organometallic Chemistry

Phone: (65) 6316 8905

E-mail: pakhing@ntu.edu.sg

Webpage: http://www.ntu.edu.sg/home/pakhing/


Research Interest

The research projects pursued by my research team involve asymmetric hydroamination and hydrophosphination reactions, insertion and coupling reactions, synthesis and coordination chemistry of chiral sulfoxide complexes, development of 2-D ROESY NMR techniques in stereochemical analysis, asymmetric synthesis of phosphines and heterocycles and development of chiral metal complexes for asymmetric catalysis. We are particularly interested in the synthesis of enantiomerically pure tertiary phosphines and diphosphines containing both the stereogenic phosphorus centres and some selected functionalities. This class of functionalized P-chiral ligands has long been considered as powerful auxiliaries for homogenous asymmetric catalysis.

PHLeung_2

An efficient approach to generate the desired stereoisomeric form of a particular ligand by means of an unusual exo-endo stereochemically controlled asymmetric Diels-Alder reaction, using a family of specially designed chiral organometallic complexes as the reaction promoter shave been developed.

PHLeung

With these catalysts, it is now possible to produce one particular target molecule in a controllable and specific manner. Currently, these findings are applied to the synthesis of new anti-cancer gold drugs. Thus far, preliminary biological tests indicate that these new drugs exhibit high activity towards various human cancerous diseases with minimal side effects. The catalytic properties of gold complexes containing these newly generated chiral phosphines are also being investigated.


Selected Publications

  1. M.Yuan, S.A.Pullarkat, Y.Li, Z.Y.Lee and P.H.Leung, , Organometallics, 2010, 29(16), 3582-3588.

  2. Y.Huang, S.A.Pullarkat, Y.Li and P.H.Leung, Chem. Commun., 2010, 46, 6950-6952.

  3. S.Chen, K.P.Ng, S.A.Pullarkat, F.Liu, Y.Li and P.H.Leung, Organometallics, 2010, 29(15), 3374-3386.

  4. D.Luo, S.A.Pullarkat, Y.X.Li and P.H.Leung, Organometallics, 2010, 29(4), 893-903.

  5. Y.Mingjun, S.A.Pullarkat, L.Yongxin, F.Liu, P.T.Pham, K.W.Tan and P.H.Leung, Inorg. Chem., 2010, 49(3), 989-996.

  6. Y.Huang, S.A.Pullarkat, Y.Mingjun, Y.Ding, L.Yongxin and P.H.Leung, Organometallics, 2010, 29(3), 536-542.