XING Bengang
xin wei

Associate Professor

Assistant Chair (Academic)
Deputy Head (Academic)

Education: B.Sc., Xinjiang Normal University; Ph.D., Nanjing University; Post-doc: Stanford University, University of California, HKUST

Research Area: Chemical Biology, Bio-Fluorescent Imaging;
Pharmaceutical Chemistry, Nanomedicine

Phone: (65) 6316 8758

E-mail: Bengang@ntu.edu.sg

Webpage: http://www.ntu.edu.sg/home/bengang/



Research Interest


1) Fluorescent Imaging (Chemical Biology/Bioorganic chemistry): Fluorescent imaging chemistry has currently attracted a great deal of academic attention in the fields of medicinal chemistry and biological science. So far, fluorescent imaging chemistry has been widely employed to screen potential drug candidates, identify the specific biomolecules, report the significant biological pathways and even monitor the early stage of diseases (cancer or bacterial infections) in vitro, in the cell or living system. In this project, we are aiming to design and prepare a series of "novel" fluorescent and luminescent imaging probes (including preparation of organic fluorophores, "photocaged or photoactive" systems, fluorescent labeled peptide/glycopeptides drug derivatives and/or fluorescent nanoparticles or functional polymers etc) for effective detection of bioactive molecules, screening of drug inhibitors or monitoring of drug reaction process in living cells.

2) Nanomedicine/Nanobiotechnology: Among the various types of nanomaterials, inorganic nanoparticles, rods and wires are particular attractive ones which exhibit highly interesting optical, electronic, Raman and magnetic properties and can serve as versatile platforms for exploring many facets in biomedical applications. In this project, we will develop the unique nanomaterials (such as gold, silver, magnetic nanoparticles or nanorods/wires and fluorescent quantum dots or upconversion nanoparticles etc) and their self-assembly or conjugates with affinity ligands including small organic molecules, peptide substrates or nucleic acid aptamer derivatives etc. These nanomaterials conjugates can be applied as biomedicine, biosensors or “transporters” for effective screening/detection of bio-molecules, efficient drug/gene delivery, biocatalyst and fluorescent monitoring of bio-functions in vitro or in living cells.

3) Biomaterials: Through the hydrogen bonding or other weak interactions among the small molecules, peptides or polysaccharides, these bioactive molecules can readily self-assemble into soft-nanomaterial-hydrogel, a brand new functional biomaterials, which consist of three dimensional and elastic networks with a lot of water filling in the interstitial spaces. In this project, we will design and prepare the small molecular weight hydrogel system based on peptides or other natural products which are environmentally sensitive to biological stimulate including light, pH, temperature, or enzymatic interactions for the targeted control of bioactive molecules delivery and precise mimic of cellular functions.

 


Selected Publications

  1. Y. M. Yang, Q. Shao, R. Deng, C. Wang, X. Teng, K. Cheng, Z. Cheng, L. Huang, Z. Liu, and X. G. Liu, B. G. Xing*. “In Vitro and In Vivo Uncaging and Bioluminescence Imaging through Photocaged Upconversion Nanoparticles.” Angew. Chem. Int. Ed., 2012, 51, 3125-3129. Selected as “hot paper” and “Inside cover” in Angew chem.

  2. Q. Shao, B. G. Xing*. “Enzyme Responsive Luminescent Ruthenium (II) Cephalosporin Probe for Intracellular Imaging and Photoinactivation of Antibiotics Resistant Bacteria.” Chem. Comm. 48, 1739-1741, 2012. Featured as “backcover” in Chem. Commun. highlighted by ACS Noteworthy Chemistry.

  3. F. Liu, Y. Lim, A. Soh, M. Harini, B. Surajit and B. G. Xing.* “Lipopolysaccharide Neutralizing Peptide-Porphyrin Conjugates for Effective Photo-inactivation and Intracellular Imaging of Gram-Negative Bacteria.” Bioconjugate Chem. 2012, 15, 1639-1647.

  4. B. G. Xing*, T. T. Jiang, W. Bi, Y. Y. Yang, E. Yeow etc. “Multifunctional Divalent Vancomycin: The Fluorescent Imaging and Photodynamic Antimicrobial Properties for Drug Resistant Bacteria.” Chem. Comm. 47, 1601-1603, 2011.

  5. Q. Shao, and B. G. Xing*. “Photoactive Molecules for Applications in Molecular Imaging and Cell Biology.” Chem. Soc. Rev. 39, 2835-2846, 2010.

  6. R. R. Liu; R. S. Liew; J. Zhou; B. G. Xing*. “A Simple and Specific Assay for Real Time Colorimetric Visualization of Beta-Lactamase activity by Using Gold Nanoparticles.” Angew. Chem. Int. Ed. 46, 8799-8803, 2007.